By car
From Milan (129 Kms):
Take the A7 Highway in direction of Genoa, continue on the A21 Highway in direction of Turin till the exit of Alessandria Sud (from highway Milan - Serravalle); then drive the State Road (SS30) for 15/20 minutes to reach the town (30 kms ca).
Or else : go on the A7 Highway as far as the exit of Tortona, continue to Alessandria on the A21 Highway till the exit of Alessandria Est; then follow the indications to Acqui Terme.
From Genoa (75 Kms):
Go on the A26 Highway as far as Ovada's Castle, then continue on the State Road (SS30) till Acqui Terme (25 kms ca).
From Turin (105 Kms):
Exit in Alessandria Sud (from Turin - Piacenza A21 Highway), drive on the State Road (SS30) for 15/20 minutes to reach the town (30 kms ca).
Or else : go along the A21 Highway in direction of Piacenza, exit in Asti Est, continue to Nizza Monferrato and follow the indications to Acqui Terme (50 km circa).
From Bologna (256 Kms):
After the West Bypass, take the A14 Highway and drive for about 0,5 Km, go along the A1 Highway, then on the A21 Highway; exit in Alessandria and continue on the State Road (SS30) in direction of Acqui Terme.

By train
From Milan:
Departure from Central Station, change train in Voghera or Mortara or Tortona stations to Alessandria and here change again to Acqui Terme.
From Turin:
Departure from Porta Nuova Station, change train in Asti or Alessandria stations to Acqui Terme (according to the time there are direct connections from Turin to Acqui Terme).
From Genoa:
Departure from Principe or Brignole Stations to Acqui Terme (direct connection).

By Pullman
From Milan:
Departure from Milano Famagosta Station (Arfea line) in direction of Acqui Terme (stop by Train Station, that is 10 minutes far from the hotel) from monday to friday, no sathurday or festivities)
From Turin:
Departure from Corso Vittorio Emanuele in direction of Acqui Terme (stop by Train Station, that is 10 minutes far from the hotel, all days, no festivities)